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The Tabas laboratory studies the cellular biology of cardiometabolic disease, with an emphasis on the molecular-cellular mechanisms of advanced atherosclerosis and hepatic insulin resistance and NASH in obesity, and the links between these processes.

The studies on advanced atherosclerosis have focused on integrated processes that combine to promote advanced plaque progression, with a focus on defective clearance of apoptotic cells (efferocytosis) and impaired inflammation resolution. In the efferocytosis field, current studies are focused on (a) cell biological pathways triggered by macrophage metabolism of ingested and degraded apoptotic cells, particularly pathways related to inflammation resolution; and (b) linking macrophages processes that promote atherosclerosis progression to both human genetic risk factors for coronary artery disease, i.e., polymorphisms that regulate specific genes, as well as systemic insulin resistance. The inflammation resolution project has a strong focus on processes that promote plaque regression and on the therapeutic potential of promoting resolution, e.g., through the use of atherosclerosis-targeted nanoparticles packaged with resolution mediators.  Additionally, an exciting new area in the lab involves identifying specific mechanistic links between impaired resolution pathways and clonal hematopoiesis of indeterminate potential (CHIP), which is a major risk factor for atherosclerosis and coronary artery disease in humans over the age of 60.

The lab's studies on hepatic insulin resistance, which is an important driver of atherosclerosis, led to the discovery of a new calcium-stimulated pathway in hepatocytes that plays a key role in glucagon-mediated excessive glucose production, insulin resistance, fatty liver, dyslipidemia, impaired thrombolysis, and adipose tissue inflammation in the setting of obesity and type 2 diabetes. Ongoing studies are investigating (a) how the pathway may promote atherosclerotic plaque progression by affecting plaque macrophages; and (b) strategies to translate our discoveries into new types of drugs to treat type 2 diabetes and prevent diabetes-driven atherosclerotic plaque progression.

Related to the lab's metabolism work, we study hepatocyte pathways in non-alcoholic steatohepatitis (NASH), with current investigations focused on (a) the role of a transcription factor called TAZ in both NASH fibrosis and NASH-associated hepatocellular carcinoma; (b) new mechanistic insight into known human genetic risk factors for NASH fibrosis; and (c) new therapeutic strategies to prevent steatosis-to-NASH progression based on our findings.

The overall approach of the laboratory is to elucidate in-depth mechanisms using molecular-cell biological approaches; test causation in normal physiology and disease models using genetically engineered mice; probe relevance to humans through the study of normal and diseased human tissues and human genetics; and conceive and test novel and mechanism-based therapies in the cardiometabolic arena. Our human genetics studies are being conducted in collaboration with the CUMC Cardiovascular and Metabolic Precision Medicine Program, led by Dr. Muredach Reilly, and include plans to study human iPSC-derived macrophages that can be genetically engineered using CRISPR/Cas9 to mimic or "correct" disease-causing human mutations. We also have collaborations with Dr. Danish Saleheen at Columbia, who directs a translational program studying humans who have heterozygous and homozygous null mutations in thousands of individual genes.

The laboratory's philosophy is one of collaboration, not competition, and emphasis is placed on long-term, in-depth, and rigorous studies. Dr. Tabas places great emphasis on mentoring, particularly fostering independence, and career guidance. His trainees have had great success in career development grants from the NIH (K99/R00) and American Heart Association and subsequently with NIH R01 grants soon after leaving the lab for independent tenure-track Assistant Professorships at major university research organizations.

Postdoctoral Research Position:
The laboratory of Dr. Ira Tabas (http://www.tabaslab.com) at Columbia University Irving Medical Center is seeking a talented postdoctoral research scientist with interest and expertise in molecular-cellular mechanisms related to atherosclerosis, particularly in the area of macrophage biology. Areas of particular interest include linking macrophages processes that promote atherosclerosis progression to (1) macrophage metabolic pathways ("immunometabolism"); (2) human genetic risk factors for coronary artery disease; and (3) systemic insulin resistance.

Candidates with the following qualifications will be considered: (1) a Ph.D. or M.D/Ph.D., with no more than 3 years post-graduation for PhD graduates; (2) first author high-quality publications published in first-rate journals; (3) experience in molecular genetics and molecular-cellular biology, with an understanding of immunometabolism and/or human genetics; (4) interest in the above areas; and (5) excellent communication skills, particularly the ability to comprehend rapidly spoken English and to speak English fluently, both in 1:1 discussions and during seminar presentations..

Interested candidates who meet these qualifications should send cover letter and CV to iat1@columbia.edu. Columbia University Irving Medical Center is an Equal Opportunity/Affirmative Action Employer.



Ira Tabas, MD, PhD

Richard J. Stock Professor and Vice-Chair of Research
Department of Medicine
Professor of Pathology & Cell Biology (in Physiology and Cellular Biophysics)
Columbia University Medical Center


Department of Medicine
Columbia University

630 West 168th Street
New York, NY 10032


Office: PH 8-East-105F
Laboratory: PH 9-405/406
Tel (office): 212-305-9430
Tel (lab): 212-305-5669
Fax: 212-305-4834
iat1@columbia.edu



What's New?

Press Release

The Nose Knows: Pungent Compound Associated with Improvements in Atherosclerotic Plaque By Eric Raible - January 30, 2020

Targeting liver enzyme may combat obesity-induced diabetes by Arlene Weintraub | Mar 26, 2018

Belly Fat Promotes Diabetes Under Orders from Liver
In obese mice, a liver enzyme inflames fat, increasing insulin resistance
March 21, 2018

Change in Mitochondria is Critical for Clearing Dead Cells.
September 21, 2017

SCIENCE
PODCAST


TABAS AND GLASS, 339 (6116): 166-172

January 11, 2013

Ira Tabas [of Columbia University’s Department of Medicine] reviews recent advances in anti-inflammatory therapies in treating and preventing chronic disease. “Inflammation, once it gets going, can lead to tissue destruction. So the very elements of inflammation that can destroy the invading organisms can also destroy host tissue. And when tissue gets damaged, it can lead to tissue disfunction, according to Dr. Tabas.


Copyright © 2018 Ira Tabas, MD, PhD. All Rights Reserved.